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Miguel A. Guzman, M.D.

Director, Division of Pediatric Pathology; Professor
Department of Pathology

Courses Taught

Director: pediatric pathology elective (PA-402), neuropathology elective; Lecturer: neuroscience module, endocrine module, neuropathology topics (monthly), brain cutting

Education

Fellowships
Pediatric pathology, St. Christopher's Hospital for Children
Neuropathology, University of Pennsylvania
Pediatric pathology, Boston Children's Hospital

Residency
Anatomic pathology, SUNY Downstate Medical Center, Brooklyn, New York

Medical School
Universidad Industrial de Santander School of Medicine, Columbia

Publications and Media Placements

Recent Publications

  • Mehta S, Kurashima K, Manithody C, Ohkura T, Morfin S, Bagwe A, Syn M, Sims A, Kolli S, Whalen C, Jain A, Guzman M, Besmer S, Jain S, Buchanan P, Pereira K, Lin CJ, Hartmann B, Holst JJ, Long J, Miyata S, McHale M, Hutchinson C, Jain AK. Distal Recirculation of Enteral contents Augmented Mechanically (DREAM) Promotes Intestinal Adaptation and Restores Enterohepatic Signaling in Short Bowel Syndrome. Gastroenterology. 2026 Jun 10:S0016-5085(26)06948-9. doi: 10.1053/j.gastro.2026.05.024. Epub ahead of print. PMID: 42269947.
  • Frolov A, Maglasang M, Guzman M, Echols MS, Daly DT. Coexistence of Rheumatoid Arthritis, Cerebrovascular Disease, and Alzheimer's Disease: A Case Study With Genetic Insights. Cureus. 2026 Feb 27;18(2):e104395. doi: 10.7759/cureus.104395. PMID: 41913828; PMCID: PMC13033329.
  • Ngo ALT, Guzman M, Duff D. Infantile Subacute Brainstem Infarction and the Presence of Incidental Ectopic Lymphoid Tissue: A Rare Case. Cureus. 2025 Oct 30;17(10):e95753. doi: 10.7759/cureus.95753. PMID: 41328150; PMCID: PMC12664773.
  • Mehta S, Manithody C, Kurashima K, Swiderska-Syn M, Miyata S, Nazzal M, Bagwe A, Jain S, Guzman M, Besmer S, McHale M. 2025. Intestinal rehabilitation is driven by a novel chyme recirculation system. Clin Nutr ESPEN, 69, p.1155.
  • Frolov A, D'sa E, Henderson C, Guzman MA, Hayat G, Martin JR 3rd. Complex Genetic Framework in Familial Amyotrophic Lateral Sclerosis With a C9ORF72 Mutation: A Case Report. Cureus. 2024 Dec 19;16(12):e76027. doi: 10.7759/cureus.76027. PMID: 39835009; PMCID: PMC11743604.
  • Frolov A, Atwood SG, Guzman MA, Martin JR 3rd. A Rare Case of Polymicrogyria in an Elderly Individual With Unique Polygenic Underlining. Cureus. 2024 Nov 23;16(11):e74300. doi: 10.7759/cureus.74300. PMID: 39717325; PMCID: PMC11665267.
  • Manithody C, Denton C, Mehta S, Carter J, Kurashima K, Bagwe A, Swiderska-Syn M, Guzman M, Besmer S, Jain S, McHale M, Qureshi K, Nazzal M, Caliskan Y, Long J, Lin CJ, Hutchinson C, Ericsson AC, Jain AK. Intraduodenal fecal microbiota transplantation ameliorates gut atrophy and cholestasis in a novel parenteral nutrition piglet model. Am J Physiol Gastrointest Liver Physiol. 2024 Nov 1;327(5):G640-G654. doi: 10.1152/ajpgi.00012.2024. Epub 2024 Aug 20. PMID: 39163019; PMCID: PMC11559648.
  • Frolov A, Guzman MA, Hayat G, Martin JR 3rd. Two Cases of Sporadic Amyotrophic Lateral Sclerosis With Contrasting Clinical Phenotypes: Genetic Insights. Cureus. 2024 Mar 12;16(3):e56023. doi: 10.7759/cureus.56023. PMID: 38606235; PMCID: PMC11008550.
  • Dilli C, Mi W, Guzman MA. Metastatic Bladder Urothelial Carcinoma Masquerading as Myositis. J Med Cases. 2024 Jul;15(7):130-135. doi: 10.14740/jmc4236. Epub 2024 Jun 19. PMID: 38993807; PMCID: PMC11236334.
  • Kiaei B, Chaudhry M, Banerjee S, Brewer J, Chen Y, Khasiyev F, Guzman MA, Hayat G. Spontaneous development of myasthenia gravis and myositis following treatment with pembrolizumab: a case report. BMC Neurol. 2024 Jun 1;24(1):184. doi: 10.1186/s12883-024-03684-2. PMID: 38824498; PMCID: PMC11143698.
  • Stram MN, Seifert AC, Cortes E, Akyatan A, Woodoff-Leith E, Borukhov V, Tetlow A, Alyemni D, Greenberg M, Gupta A, Krausert A, Mecca L, Rodriguez S, Stahl-Herz J, Guzman MA, Delman B, Crary JF, Dams-O'Connor K, Folkerth RD. Neuropathology of Pediatric SARS-CoV-2 Infection in the Forensic Setting: Novel Application of Ex Vivo Imaging in Analysis of Brain Microvasculature. Front Neurol. 2022 May 24;13:894565. doi: 10.3389/fneur.2022.894565. PMID: 35685741; PMCID: PMC9170881.
  • Frolov A , Coomar L , Guzman M, Martin III, J. 2022. Mixed Cerebrovascular and Alzheimer’s Type Pathology Mimicking Lewy Body Disease and Its Possible Contribution to Cognitive Impairment in Elderly Patients with Bipolar Disorder/Schizophrenia. Open J Pathol, 12, 88-99. doi: 10.4236/ojpathology.2022.123011.
  • Maglasang MNA, Frolov A, Guzman M, Echols S, Daly D. 2022. Cerebral Vascular Density and Its Possible Correlation with Alzheimer Disease Progression in Elderly Individuals with Rheumatoid Arthritis. FASEB J, 36:. https://doi.org/10.1096/fasebj.2022.36.S1.L6386
  • Hockman JT, El Tecle NE, Urquiaga JF, Alexopoulos G, Guzman MA, Coppens J. Dissemination Patterns and Short-Term Management of Multifocal Rosette-Forming Glioneuronal Tumors. World Neurosurg. 2021 May;149:86-93. doi: 10.1016/j.wneu.2021.02.043. Epub 2021 Feb 18. PMID: 33610864.
  • Li Y, Miller CA, Shea LK, Jiang X, Guzman MA, Chandler RJ, Ramakrishnan SM, Smith SN, Venditti CP, Vogler CA, Ory DS, Ley TJ, Sands MS. Enhanced Efficacy and Increased Long-Term Toxicity of CNS-Directed, AAV-Based Combination Therapy for Krabbe Disease. Mol Ther. 2021 Feb 3;29(2):691-701. doi: 10.1016/j.ymthe.2020.12.031. Epub 2021 Jan 1. PMID: 33388420; PMCID: PMC7854295.
  • Gauntner TD, Karumuri M, Guzman MA, Starnes SE, Besmer S, Pinz H, Braddock SR, Andreone TL. Hirschsprung Disease in an Infant with L1 syndrome: Report of a New Case and a novel L1CAM variant. Clin Case Rep. 2021 Feb 4;9(3):1518-1523. doi: 10.1002/ccr3.3816. PMID: 33768880; PMCID: PMC7981724.
  • Anderson WJ, Sharma A, Guzman MA, Chung SM. A 26-Year-Old Woman With Diplopia and Nystagmus. J Neuroophthalmol. 2020 Dec;40(4):533-537. doi: 10.1097/WNO.0000000000000959. PMID: 32441901.
  • Navalkele P, Guzman M, Kirby A, Pinz H, Kemp J. Familial Pediatric Clear Cell Meningioma With Germline SMARCE1 Mutation in the United States. J Neuropathol Exp Neurol. 2020 Nov 1;79(11):1250-1252. doi: 10.1093/jnen/nlaa115. PMID: 33085974; PMCID: PMC7577515.
  • Zhang T, Guzman MA, Batanian JR. Narrowing down the Common Cytogenetic Deletion 14q to a 5.6-Mb Critical Region in 1p/19q Codeletion Oligodendroglioma-Relapsed Patients Points to Two Potential Relapse-Related Genes: SEL1L and STON2. Cytogenet Genome Res. 2020;160(6):316-320. doi: 10.1159/000509020. Epub 2020 Jun 24. PMID: 32575107.
  • Barnes A, Wang MM, Feltes J, Ko J, Guzman MA. Subependymal Giant-cell Astrocytoma Masquerading as Restrictive Eating Disorder and Depression in an Adolescent. Innov Clin Neurosci. 2020 Jan 1;17(1-3):10-13. PMID: 32547840; PMCID: PMC7239562.
  • Anderson WJ, Sharma A, Guzman MA, Chung SM. A 26-Year-Old Woman With Diplopia and Nystagmus. J Neuroophthalmol. 2020 Dec;40(4):533-537. doi: 10.1097/WNO.0000000000000959. PMID: 32441901.
  • Guzman M, Manithody C, Krebs J, Denton C, Besmer S, Rajalakshmi P, Jain S, Villalona GA, Jain AK. Impaired Gut-Systemic Signaling Drives Total Parenteral Nutrition-Associated Injury. Nutrients. 2020 May 20;12(5):1493. doi: 10.3390/nu12051493. PMID: 32443928; PMCID: PMC7284746.
  • Sosa AC, Kariuki B, Gan Q, Knutsen AP, Bellone CJ, Guzmán MA, Barrera LA, Tomatsu S, Chauhan AK, Armbrecht E, Montaño AM. Oral immunotherapy tolerizes mice to enzyme replacement therapy for Morquio A syndrome. J Clin Invest. 2020 Mar 2;130(3):1288-1300. doi: 10.1172/JCI125607. PMID: 31743109; PMCID: PMC7269574.

Honors and Awards

  • Faculty Excellence in Education Award - Dean’s Office, Saint Louis University School of Medicine
  • Best Lecturer - Department of Neurology, Saint Louis University School of Medicine
  • Faculty of the Year - Department of Pathology, Saint Louis University School of Medicine (2013, 2016)

Professional Organizations and Associations

  • Children’s Oncology Group
  • Society for Pediatric Pathology
  • United States and Canadian Academy of Pathology
  • American Association of Neuropathologists

Community Work and Service

  • Member, Case Review Team, Fetal Infant Mortality Review (FIMR) Maternal Child and Family Health Coalition, Saint Louis, Missouri
  • Member, Parents Association, Competition Team, Axiom Taekwondo Martial Arts Academy